教育经历

1/2015-12/2018  博士，兽医病理生物学，堪萨斯州立大学，美国

8/2011-7/2014   硕士, 动物营养与饲料科学，中国科学院大学，中国

8/2007-7/2011   本科，动物医学，西南大学，中国

8/2008-7/2011   本科，英语（第二专业），西南大学，中国

荣誉及奖励

2018    Samuel M.Kruckenberg奖学金

2018    研究生院学术旅行奖励，堪萨斯州立大学

2018    兽医系学术旅行奖励，堪萨斯州立大学

2014    优秀硕士毕业论文，中国科学院大学

2014    优秀毕业生，中国科学院大学

2014    中科院广州教育基地第十三届研究生学术报告会硕士组三等奖，中国科学院大学研究生学术论坛广州分会

2009    国家本科生科技创新基金项目，西南大学

2009    国家励志奖学金，西南大学

科研经历

博士后1/2019-至今 导师：Sherry Fleming教授

    Postdoc Fellowship，Division of Biology,  Kansas State University, Manhattan, KS [美国]

    研究方向：不同性别肠缺血再灌注损伤的机制差异

博士研究生1/2015-12/2018 导师：Philip R. Hardwidge教授

    Graduate Research Assistant，Department of Diagnostic Medicine /Pathobiology,  Kansas State University, Manhattan, KS [美国]

    研究方向：肠道致病菌III型分泌系统毒力效应蛋白对NF-kappaB信号途径的机制研究

硕士研究生8/2011-7/2014 导师：印遇龙院士、李铁军研究员

    动物营养与饲料科学，中国科学院大学，北京，中国

    研究方向：谷氨酸缓解呕吐毒素对仔猪毒害作用的研究

大学本科9/2007-7/2011 导师：彭远义教授、王豪举教授

    动物医学，西南大学，重庆，中国

    研究方向：混合感染模型中大肠杆菌诱生抗原基因的初步研究

联系方式

e-mail: miaomiaowu0316@hunau.edu.cn 

地址：湖南农业大学第二教学楼 

发表SCI收录文章（ Google Scholar检索报告 2018. 09. 24）

1.Wu, M.M., H. Xiao, G. Liu, S. Chen, B.E. Tan, W.K. Ren, F.W. Bazer, G.Y. Wu, and Y.L. Yin.  Glutamine promotes intestinal SIgA secretion through intestinal microbiota and IL-13. Molecular Nutrition & Food Research.  2016, 60, 1637-1648. (Top Journal, Front Cover) citations: 20 (2017 IF: 5.151)一区

2.Xiao, H.*, M.M. Wu*, F.Y. Shao, G.P. Guan, B. Huang, B.E. Tan, and Y.L. Yin. N-Acetyl-L-cysteine protects the enterocyte against oxidative damage by modulation of mitochondrial function. Mediators of Inflammation.  2016, 2016, 8364279. (*同等贡献) citations: 1 (2017 IF: 3.549)二区

3.Xiao, H.*, M.M. Wu*, F.Y. Shao, B.E. Tan, T.J. Li, W.K. Ren, J. Yin, J. Wang, Q.H. He, Y.L. Yin, and Y.Q. Hou.  Metabolic profiles in the response to supplementation with composite antimicrobial peptides in piglets challenged with deoxynivalenol. Journal of Animal Science.  2015, 93, 1114-1123. (*同等贡献) (Top Journal) citations: 10 (2017 IF: 1.711) 一区

4.Yin, J.*, M.M. Wu*, J.L. Duan, G. Liu, Z.J. Cui, J. Zheng, S. Chen, W.K. Ren, J.P. Deng, X.W. Tan, N.A. Al-Dhabi, V. Duraipandiyan, P. Liao, T.J. Li, and Y.L. Yin. Pyrrolidine dithiocarbamate inhibits NF-κB activation and upregulates the expression of Gpx1, Gpx4, occludin, and ZO-1 in DSS-Induced Colitis. Applied Biochemistry and Biotechnology.  2015, 177, 1716-1728. (*同等贡献) citations: 14 (2017 IF: 1.797)三区

5.Wu, M.M., H. Xiao, W.K. Ren, J. Yin, J.Y. Hu, J.L. Duan, G. Liu, B.E. Tan, X. Xiong, A.O. Oso, O. Adeola, K. Yao, Y.L. Yin, and T.J. Li.  An NMR-based metabolomic approach to investigate the effects of supplementation with glutamic acid in piglets challenged with deoxynivalenol. PLoS One.  2014, 9, e113687. citations: 11 (2017 IF: 2.766)一区

6.Wu, M.M., H. Xiao, W.K. Ren, J. Yin, G. Liu, L.L. Li, C.M. Nyachoti, T.J. Li, Y.L. Yin, G.Y. Wu.  Therapeutic effects of glutamic acid in piglets challenged with deoxynivalenol. PLoS One.  2014, 9, e100591. citations: 34 (2017 IF: 2.766)一区

7.Wu, M.M., J.M. Rowe, S.D. Fleming. Eicosanoid production varies by sex in mesenteric ischemia reperfusion injury. Clinical immunology. 2020（已接收）(2018 IF: 3.368)二区

8.Wu, M.M., H. Xiao, F.Y. Shao, B.E. Tan, S.L. Hu. Arginine accelerates intestinal health through cytokines and intestinal microbiota. International Immunopharmacology. 2020, 81, 106029. ( 2018 IF: 3.361) 三区

9.Wu, M.M. and P.R. Hardwidge.  Hsp90 interacts with the bacterial effector NleH1. Pathogens, 2018. 7(4). (2018 IF: 3.405)二区

10. Wu, M.M., S. El Qaidi, and P.R. Hardwidge. SseL deubiquitinates RPS3 to inhibit its nuclear translocation. Pathogens, 2018. 7(4). (2018 IF: 3.405)二区

11. Yin, J.*, M.M. Wu*, Y.Y. Li, W.K. Ren, H. Xiao, S. Chen, C.Y. Li, B.E. Tan, H.J. Ni, X. Xiong, Y.Z. Zhang, X.G. Huang, R.J. Fang, T.J Li, and Y.L. Yin.  Toxicity assessment of hydrogen peroxide on Toll-like receptor system, apoptosis, and mitochondrial respiration in piglets and IPEC-J2 cells. Oncotarget.  2017, 8, 3124-3131. (*同等贡献) citations: 3 (2017 IF: 5.168)

12. El Qaidi, S., M.M. Wu, C.R. Zhu, and P.R. Hardwidge.  Salmonella, E. coli, and Citrobacter type III secretion system effector proteins that alter host innate immunity. Advances in Experimental Medicine and Biology. 2018. (2016 IF: 1.881)

13. Park, J.B., Y.H. Kim, Y.K. Yoo, J.Y. Kim, S.H. Jun, J.W. Cho, S. El Qaidi, S. Walple, S. Monaco, A. Garcia-Garcia, M.M. Wu, M.P. Hays, R.H. Guerrero, J. Angulo, P.R. Hardwidge, J.S. Shin, and H.S. Cho.  Structural basis for arginine glycosylation of host proteins by bacterial effector proteins. Nature Communications.  2018, 9, 4283. (2017 IF: 12.353)一区

14. He, F., Z. Yin, C.L. Wu, Y.Y. Xia, M.M. Wu, P. Li, H.H. Zhang, Y.Y. Yin, N.Z. Li, G.Q. Zhu, W.K. Ren, Y.Y. Peng. L-serine lowers lung inflammatory responses during Pasteurella multocida infection, Infection and Immunity. 2020, 87, 12. (2018 IF: 3.16) 三区

15. Xiao, H., L.M. Zeng, F.Y. Shao, B. Huang, M.M. Wu, B.E. Tan, and Y.L. Yin.  The role of nitric oxide pathway in arginine transport and growth of IPEC-1 cells. Oncotarget. 2017, 8, 29976–29983. citations: 2 (2017 IF: 5.168)

16. Xiong, X., H.S. Yang, B.E. Tan, C.B. Yang, M.M. Wu, G. Liu, W.S. Kim, T.J. Li, L.L. Li, J.J. Wang, G.Y. Wu, and Y.L. Yin.  Differential expression of proteins involved in energy production along the crypt-villus axis in early-weaning pig small intestine. American Journal of Physiology Gastrointestinal and Liver Physiology.  2015, 309, G229-237. citations: 25 (2016 IF: 3.468)

17. Xiao, H.*, F.Y. Shao*, M.M. Wu, W.K. Ren, X. Xiong, B.E. Tan, and Y.L. Yin.  The application of antimicrobial peptides as growth and health promoters for swine. Journal of Animal Science and Biotechnology.  2015, 6, 19. (*equal contribution) citations: 22 (2017 IF: 3.205)

18. Xiao, H., B.E. Tan, M.M. Wu, F.Y. Shao, and Y.L. Yin.  Regulatory Mechanism of mTOR Signaling Pathway on Cell Energy Metabolism.  SCIENTIA SINICA Vitae.  2015, 45, 1124-31. citations: 1

19. Wang, J., G.R. Li, B.E. Tan, X, Xiong, X.F. Kong, D.F. Xiao, L.W. Xu, M.M. Wu, B. Huang, S.W. Kim, and Y.L. Yin.  Oral administration of putrescine and proline during the suckling period improves epithelial restitution after early weaning in piglets. Journal of Animal Science.  2015, 93, 1679-1688. (Top Journal) citations: 23 (2017 IF: 1.711)一区

20. Yin, J., W.K. Ren, H.Q. Hou, M.M. Wu, H. Xiao, J.L. Duan, Y.R. Zhao, T.J. Li, Y.L. Y.L. Yin, G.Y. Wu, and C.M. Nyachoti.  Use of homoarginine for measuring true ileal digestibility of amino acids in food protein. Amino Acids.  2015, 47, 1795-1803. citations: 7 (2017 IF: 2.906)

21. Duan, J.L., J. Yin, W.K. Ren, M.M. Wu, S. Chen, Z.J. Cui, X. Wu, R.L. Huang, T.J. Li, and Y.L. Yin.  Pyrrolidine dithiocarbamate restores gastric damages and suppressive autophagy induced by hydrogen peroxide. Free Radical Research.  2015, 49, 210-218. citations: 6 (2017 IF: 3.038)

22. Duan JL*, J. Yin*, M.M. Wu, P. Liao, D. Deng, G. Liu, Q.Q. Wen, Y.F. Wang, W. Qiu, Y. Liu, X.L. Wu, W.K. Ren, B.E. Tan, M.H. Chen, H. Xiao, L. Wu, T.J. Li, C.M. Nyachoti, O. Adeola, and Y.L. Yin. Dietary glutamate supplementation ameliorates mycotoxin-induced abnormalities in the intestinal structure and expression of amino acid transporters in young pigs. PLoS one. 2014, 9, e112357. (*equal contribution) citations: 26 (2017 IF: 2.766)一区

23. Ren, W.K. *, J. Yin*, M.M. Wu, G. Liu, G. Yang, Y. Xiong, D. Su, L. Wu, T.J. Li, S. Chen, J.L. Duan, Y.L. Yin, and G.Y. Wu.  Serum amino acids profile and the beneficial effects of L-arginine or L-glutamine supplementation in dextran sulfate sodium colitis. PLoS One.  2014, 9, e88335. citations: 90 (2017 IF: 2.766)一区

24. Yin, J., M.M. Wu, H. Xiao, W.K. Ren, J.L. Duan, G. Yang, T.J. Li, and Y.L. Yin.  Development of an antioxidant system after early weaning in piglets. Journal of Animal Science.  2014, 92, 612-619. (Top Journal) citations: 90 (2017 IF: 1.711)一区

25. Ren, W.K., W. Luo, M.M. Wu, G. Liu, X.L. Yu, K. Yao, T.J. Li, Y.L. Yin, and G.Y. Wu.  Dietary L-glutamine supplementation improves pregnancy outcome in mice infected with type-2 porcine circovirus. Amino Acids.  2013, 45, 479–488. citations: 69 (2017 IF: 2.906)

26. Ren, W.K., R. Yu, G. Liu, N.Z. Li, Y.Y. Peng, M.M. Wu, Y.L. Yin, Y.H. Li, A. Andrew. A.A. Fatufe, and T.J. Li.  DNA vaccine encoding the major virulence factors of Shiga toxin type 2e (Stx2e)-expressing Escherichia coli induces protection in mice. Vaccine.  2013, 31, 367-372. citations: 18 (2017 IF: 3.285)

27. Ren, W.K., M.M. Wu, W. Luo, R. Huang, Y.L. Yin, Y.H. Li, T.J. Li, and X.L. Yu.  Dietary supplementation with proline confers a positive effect in both porcine circovirus-infected pregnant and non-pregnant mice. British Journal of Nutrition.  2013, 110, 1492-1499. citations: 13 (2017 IF: 3.657)

28. Xiao, H., M.M. Wu, B.E. Tan, Y.L. Yin, T.J. Li, D.F. Xiao, and L. Li. Effects of composite antimicrobial peptides in weanling piglets challenged with deoxynivalenol: I. Growth performance, immune function, and antioxidation capacity. Journal of Animal Science.  2013, 91, 4772-4780. (Top Journal) citations: 46 (2017 IF: 1.711)一区

29. Xiao, H., M.M. Wu, B.E. Tan, Y.L. Yin, T.J. Li, D.X. Yuan, and L. Li. Effects of composite antimicrobial peptides in weanling piglets challenged with deoxynivalenol: II.  Intestinal morphology and function. Journal of Animal Science.  2013, 91, 1-7. (Top Journal) citations: 42 (2017 IF: 1.711)一区

待发表SCI论文

30. He, F., C.L. Wu, Y.Y. Xia, S.Y. Chen, H.H. Zhang, Y.Y. Yin, N.Z. Li, W.K. Ren, Y.Y. Peng, M.M. Wu.  L-serine lowers lung inflammatory responses in mice during Pasteurella multocida infection, Submitted to The Journal of Immunology, under review. (Top Journal) (2017 IF: 4.539) 一区

31. Wu, M.M., S.D. Fleming. Complement activation delay causes decreased intestinal ischemia-reperfusion injury in female mice. Submitted to The Journal of Immunology, under review. (Top Journal) (2017 IF: 4.539) 一区

发表论文（中文核心期刊）

1. 黄博，胡佳宇，吴苗苗，肖昊，张军，谭碧娥, 印遇龙. 猪胃肠道谷氨酸代谢及其对机体健康的影响[J]. 动物营养学报, 2015, 27(11): 3326-3331.

2. 吴苗苗, 肖昊, 印遇龙, 李丽立, 李铁军. 谷氨酸对脱氧雪腐镰刀菌烯醇刺激下的断奶仔猪生长性能、血常规及血清生化指标变化的干预作用 [J]. 动物营养学报, 2013, 25(7): 1587-1594.

3. 陈明洪，尹杰，邓建文，吴苗苗，肖昊，段杰林，方俊，李铁军. 氨基酸对呕吐毒素诱导的肥育猪血液生理生化损伤的干预效应[J]. 湖南农业科学, 2013, 7: 112-116.

4. 段杰林，尹杰，吴苗苗，陈明洪，肖昊，何绍平，李颖慧，王磊，黄兴国，张彬，李铁军. 脱氧雪腐镰刀菌烯醇对肠道结构与免疫功能的影响及机理 [J]. 生命科学, 2013, 25(4): 402-409.

5. 黄明明*，吴苗苗*，陈友梅，刘汉超，崔亚蓝，李能章，王豪举. 鸡大肠杆菌和沙门氏菌混合感染模型的构建[J]. 中国兽医杂志, 2012, 48: 49-51.（*同等贡献）

6. 吴苗苗，黄明明，陈友梅，李能章，王豪举. 细菌体内诱生抗原筛选技术的研究进展[J]. 动物医学进展, 2011, 32(4): 90-94.

专著教材

1. Handbook of Livestock and poultry production. 2012, Hunan Science & Technology Press. (Coauthor) (Chinese)

会议摘要，海报和口头报告

1. Wu, M.M. and P.R. Hardwidge.  SseL deubiquitinates RPS3 to inhibit its nuclear translocation.  The 99th, Annual Conference of Research Workers in Animal Disease (CRWAD).  Chicago, IL, USA, Dec 1-4, 2018. （口头报告）

2. Wu, M.M. and P.R. Hardwidge.  SseL functions as a deubiquitinase to inhibit RPS3 nuclear translocation.  17th Annual Great Plains Infectious Disease Meeting.  Lawrence, KS, Nov 4-5, 2018. （会议海报）

3. Wu, M.M. and P.R. Hardwidge.  Do T3SS effectors other than NleH1 inhibit RPS3 nuclear translocation?  15th Annual Great Plains Infectious Disease Meeting.  Lawrence, KS, Nov 4-5, 2016. （会议海报）

4. Xiao, H., M.M. Wu, F.Y. Shao, B. Huang, B.E. Tan, and Y.L. Yin.  N-acetyl-L-cysteine (NAC) protects the enterocyte against oxidative damage by preserving mitochondrial function.  The 11th National Animal Nutrition Symposium of Animal Nutrition Branch of Chinese Association of Animal Science and Veterinary Medicine.  Changsha, HN, Oct 19-21, 2012. （会议摘要）

5. Wu, M.M., H. Xiao, Y.L. Yin, L.L. Li, and T.J. Li.  Effects of glutamic acid in piglets challenged with deoxynivalenol on intestinal morphology, D-lactate and DAO.  The 11th National Animal Nutrition Symposium of Animal Nutrition Branch of Chinese Association of Animal Science and Veterinary Medicine.  Changsha, HN, Oct 19-21, 2012. （会议摘要）

6. Wu, M.M., H. Xiao, L. Wu, Y.L. Yin, L.L. Li, and T.J. Li.  Effects of glutamic acid in piglets challenged with deoxynivalenol on growth performance and antioxidation capacity.  The 11th National Animal Nutrition Symposium of Animal Nutrition Branch of Chinese Association of Animal Science and Veterinary Medicine.  Changsha, HN, Oct 19-21, 2012. （会议摘要）

7. Wu, M.M., H. Xiao, Y.L. Yin, L.L. Li, and T.J. Li.  Metabolism of glutamic acid by gastrointestinal tract.  The International Academic Conference hosted by the Coalition on National Swine Industrial Technology Innovation.  The 11th National Animal Nutrition Symposium of Animal Nutrition Branch of Chinese Association of Animal Science and Veterinary Medicine. , Changsha, HN, Oct 19-21, 2012. （会议摘要）

8. Xiao, H., M.M. Wu, Y.L. Yin, B.E. Tan, and T.J. Li.  Restore effects of composite antimicrobial peptide in deoxynivalenol-induced intestinal injury in piglet.  The 11th National Animal Nutrition Symposium of Animal Nutrition Branch of Chinese Association of Animal Science and Veterinary Medicine.  Changsha, HN, Oct 19-21, 2012. （会议摘要）

9. Xiao, H., M.M. Wu, Y.L. Yin, B.E. Tan, and T.J. Li.  Effects of composite antimicrobial peptide on alleviation of deoxynivalenol toxicity in piglets.  The 11th National Animal Nutrition Symposium of Animal Nutrition Branch of Chinese Association of Animal Science and Veterinary Medicine.  Changsha, HN, Oct 19-21, 2012. （会议摘要）

特邀审稿人

1.Research of Veterinary Science:  2019 – 至今

2.Research in Veterinary Science:  2018 – 至今

3.Medical Science Monitor:  2018 – 至今

4.Toxicology Reports:  2017 – 至今